| Fri | Jul 29 | @Phillies | L 3-10 | Roy Halladay | Charlie Morton | 45,599 |
| Sat | Jul 30 | @Phillies | L 4-7 | Cliff Lee | James McDonald | 45,737 |
| Sun | Jul 31 | @Phillies | L 5-6 | Antonio Bastardo | Tony Watson | 45,809 |
| Mon | Aug 1 | Cubs | L 3-5 | Carlos Zambrano | Paul Maholm | 22,248 |
| Tue | Aug 2 | Cubs | L 6-11 | Randy Wells | Kevin Correia | 26,109 |
| Wed | Aug 3 | Cubs | L 0-1 | Matt Garza | Chris Resop | 19,106 |
| Thu | Aug 4 | Cubs | L 6-7 | Jeff Samardzija | Daniel McCutchen | 29,317 |
| Fri | Aug 5 | Padres | L 5-15 | Aaron Harang | Jeff Karstens | 37,766 |
| Sat | Aug 6 | Padres | L 2-13 | Cory Luebke | Paul Maholm | 39,251 |
10 GB of MIL
Aug 7 · Padres beat Pirates · 7-3